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PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.19 mL | 35.94 mL | 71.88 mL |
| 0.5 mM | 1.44 mL | 7.19 mL | 14.38 mL |
| 1 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 5 mM | 0.14 mL | 0.72 mL | 1.44 mL |
*The above data is based on the productmolecular weight 1391.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18890 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1391.22 |
| Formula | C70H76Cl4N10O12 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2249944-99-6 |
| Synonyms | 0 |
| SMILES | O=C(N1CC(N(CC(NCCOCCOCCNC(CN2C(CN(C(N3[C@@H](C4=CC=C(Cl)C=C4)[C@@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[C@@H](C8=CC=C(Cl)C=C8)[C@@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C |
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