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E 2012
Catalog No. A11393 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
Flurizan
Catalog No. A12433 -
LY3039478
Catalog No. A13544 -
IMR-1A
Catalog No. A16223 -
Timosaponin b-II
Catalog No. A14591 -
gamma-secretase modulator 3
Catalog No. A15090 -
Compound W
Catalog No. A15296 -
JLK 6
Catalog No. A15301 -
PF-03084014
Catalog No. A11259 -
Flurbiprofen Axetil
Catalog No. A13662 -
L-685458
Catalog No. A15899 -
Begacestat (GSI-953)
Catalog No. A11258 -
gamma-secretase modulator 1
Catalog No. A11425 Gamma-secretase modulatorgamma-secretase modulator 1是γ-分泌酶调节剂，γ-分泌酶调节剂1可用于阿尔茨海默病。 了解更多 -
gamma-secretase modulator 2
Catalog No. A11427 -
TC-E 5006
Catalog No. A13217 -
Verubecestat (MK-8931)
Catalog No. A16113 β-secretase/BACE1 抑制剂Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂，是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。 了解更多 -
CHF5074
Catalog No. A16214 -
Z-Ile-Leu-aldehyde
Catalog No. A16215 -
BACE1-IN-4
Catalog No. A18462 BACE1 inhibitorBACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多 -
PF-06751979
Catalog No. A20066 BACE1 inhibitorPF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多 -
Umibecestat (CNP520)
Catalog No. A18987 BACE-1 inhibitorUmibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多 -
Lanabecestat
Catalog No. A12282 BACE1 inhibitorLanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多 -
BACE1-IN-1
Catalog No. A12183 BACE1 inhibitorBACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多 -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多 -
Compound E
Catalog No. A21292 -
β-Secretase Inhibitor IV
Catalog No. A21346 BACE-1 inhibitorβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多 -
AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
Apoptosis Activator 2
Catalog No. A11944 Apoptosis ActivatorApoptosis Activator 2 强烈诱导caspase-3激活，PARP裂解和DNA片段化，导致细胞破坏（依赖Apaf-1），IC50为约4μM，对HMEC，PREC或MCF-10A细胞无效。 了解更多 -
LY573636 (Tasisulam)
Catalog No. A13070 Apoptosis inducerLY573636 (Tasisulam)是一种有效的抗肿瘤剂，在体外和体内引起多种人实体瘤的生长停滞和凋亡。LY573636诱导的凋亡通过线粒体靶向机制发生。 了解更多 -
Z-FA-FMK
Catalog No. A14284 -
25-hydroxy Cholesterol
Catalog No. A13704 25-hydroxy Cholesterol是一种衍生自膳食胆固醇的侧链取代氧固醇，可抑制固醇调节元件结合蛋白（SREBPs）的裂解，从而抑制各种细胞类型中的内源性胆固醇合成。 了解更多 -
VX-765 (Belnacasan)
Catalog No. A10984 Caspase-1/4 抑制剂VX-765 (Belnacasan)是一种新型的Caspase-1抑制剂，是一种控制两种细胞因子IL-1b和IL-18生成的酶。 了解更多
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