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PROTACs

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  1. MD-224
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    MD-224

    Catalog No. A18712
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    MDM2 degrader
    MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. 了解更多
  2. PROTAC ERRα Degrader-1
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    PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  3. PROTAC ER Degrader-3
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    PROTAC ER Degrader-3

    Catalog No. A18519
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    PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多
  4. dMCL1-2
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    dMCL1-2

    Catalog No. A18378
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    MCL-1/PROTAC degrader
    dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1. 了解更多
  5. ERD-308
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    ERD-308

    Catalog No. A18446
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    ER PROTAC degrader
    ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. 了解更多
  6. THAL-SNS-032
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    THAL-SNS-032

    Catalog No. A19088
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    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
  7. PROTAC Sirt2 Degrader-1
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    PROTAC Sirt2 Degrader-1

    Catalog No. A20005
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    Sirt2 degrader
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. 了解更多
  8. VZ185
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    VZ185

    Catalog No. A18685
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    dual BRD7/9 PROTAC degrader
    VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively. 了解更多
  9. PROTAC ERRα Degrader-2
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    PROTAC ERRα Degrader-2

    Catalog No. A18904
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    ERRa degrader
    PROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  10. ARV-771
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    ARV-771

    Catalog No. A13255
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    BET degrader
    ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. 了解更多
  11. PROTAC Bcl2 degrader-1
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    PROTAC Bcl2 degrader-1

    Catalog No. A18355
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    degrader
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. 了解更多
  12. ZXH-3-26
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    ZXH-3-26

    Catalog No. A18399
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    PROTAC BRD4 degrader
    ZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM. 了解更多
  13. FKBP12 PROTAC dTAG-7
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    FKBP12 PROTAC dTAG-7

    Catalog No. A19081
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    heterobifunctional degrader
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. 了解更多
  14. PROTAC FLT-3 degrader 1
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    PROTAC FLT-3 degrader 1

    Catalog No. A18682
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    FLT-3 ITD degrader
    PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. 了解更多
  15. MT-802
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    MT-802

    Catalog No. A18589
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    BTK degrader
    MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). 了解更多
  16. PROTAC CRBN Degrader-1
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    PROTAC CRBN Degrader-1

    Catalog No. A18863
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    CRBN degrader
    PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. 了解更多
  17. BETd-260
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    BETd-260

    Catalog No. A12563
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    BET degrader
    BETd-260 is a potent BET degrader based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line. 了解更多
  18. MZP-54
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    MZP-54

    Catalog No. A19426
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    BRD3/4 degrader
    MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. 了解更多
  19. PROTAC BET degrader-2
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    PROTAC BET degrader-2

    Catalog No. A18785
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    PROTAC BET degrader
    PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. 了解更多
  20. dBET1
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    dBET1

    Catalog No. A16858
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    BRD4 protein degrader
    dBET1是基于PROTAC技术的有效BRD4蛋白降解剂，EC50为430 nM。 了解更多
  21. MZP-55
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    MZP-55

    Catalog No. A19415
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    BRD3/4 degrader
    MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. 了解更多
  22. MZ1
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    MZ1

    Catalog No. A17014
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    BRD4 protein degrader
    MZ1是BRD2和BRD3上BRD4可逆，持久和选择性去除的有效诱导剂。 了解更多
  23. dBET57
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    dBET57

    Catalog No. A19133
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    BRD4BD1degrader
    dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. 了解更多

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