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Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶（cdk）抑制剂。对于cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35，IC50值分别为4、70、35、850和75 nM。
靶点信息
| Cdc2/CyclinB | CDK2/CyclinE | CDK2/CyclinA | CDK4/CyclinD1 | |
| 4 nM | 35 nM | 70 nM | 850 nM |
| In vitro | DMSO | Warmed: 53 mg/mL (136.28 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 11 mg/mL (28.28 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.71 mL | 128.57 mL | 257.14 mL |
| 0.5 mM | 5.14 mL | 25.71 mL | 51.43 mL |
| 1 mM | 2.57 mL | 12.86 mL | 25.71 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15517 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 388.89 |
| Formula | C19H25ClN6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 212844-53-6 |
| Synonyms | NG-60 |
| SMILES | CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1 |
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