产品详情

生物活性

PX 12抑制缺氧诱导的HIF-1a转录活性（IC50 11 nM）和HT29和MCF-7肿瘤细胞的增殖（IC50分别为1.9和0.9 uM）。

靶点信息

Trx-1

溶解度 *

In vitro (25°C)	DMSO	37 mg/mL (196.48 mM)
	Water	Insoluble
	Ethanol	37 mg/mL
In vivo	2% DMSO+30% PEG 300+ddH2O	10 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	53.1 mL	265.52 mL	531.04 mL
0.5 mM	10.62 mL	53.1 mL	106.21 mL
1 mM	5.31 mL	26.55 mL	53.1 mL
5 mM	1.06 mL	5.31 mL	10.62 mL

*The above data is based on the productmolecular weight 188.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13831
作用机制	Inhibitor (抑制剂)
M. Wt	188.31
Formula	C7H12N2S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	141400-58-0
Synonyms	IV-2, PX-12, PX12
SMILES	CCC(C)SSC1=NC=CN1