Pyrotinib dimaleate

Name: Pyrotinib dimaleate
SKU: A21756

目录号: A21756

EGFR/HER2 dual inhibitor

Pyrotinib dimaleate Chemical Structure

CAS NO. 1397922-61-0

Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 s of 13 and 38 nM, respectively.

库存：现货

规格	价格	数量
1 mg	￥ 1,435.00
5 mg	￥ 4,312.00
10 mg	￥ 7,343.00
50 mg	￥ 22,022.00

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生物活性

Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 s of 13 and 38 nM, respectively.

溶解度 *

In vitro	DMSO	Insoluble
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.27 mL	61.33 mL	122.67 mL
0.5 mM	2.45 mL	12.27 mL	24.53 mL
1 mM	1.23 mL	6.13 mL	12.27 mL
5 mM	0.25 mL	1.23 mL	2.45 mL

*The above data is based on the productmolecular weight 815.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21756
作用机制	Inhibitor (抑制剂)
M. Wt	815.22
Formula	C40H39ClN6O11
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1397922-61-0
Synonyms	SHR-1258 dimaleate, SHR1258, SHR 1258
SMILES	O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/[C@@H]5N(C)CCC5.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O