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R788 (Fostamatinib)是重要的脾酪氨酸激酶（Syk）抑制剂，显示出对激酶介导的IgG Fcγ受体信号转导的功效。
靶点信息
| Syk | Adenosine A3 receptor | Adenosine transporter | Monoamine transporter | |
| 41 nM | 81 nM | 1.84 μM | 2.74 μM |
| In vitro (25°C) | DMSO | 107 mg/mL (184.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+30% PEG 300+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.23 mL | 86.13 mL | 172.27 mL |
| 0.5 mM | 3.45 mL | 17.23 mL | 34.45 mL |
| 1 mM | 1.72 mL | 8.61 mL | 17.23 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.45 mL |
*The above data is based on the productmolecular weight 580.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11926 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 580.5 |
| Formula | C23H26FN6O9P |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 901119-35-5 |
| Synonyms | R-788 |
| SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C |
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