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R788 (Fostamatinib)

R788 (Fostamatinib)

Name: R788 (Fostamatinib)
SKU: A11926

目录号: A11926

Syk 抑制剂

Product Citations (4)

R788 (Fostamatinib) Chemical Structure

CAS NO. 901119-35-5

R788 (Fostamatinib)是重要的脾酪氨酸激酶（Syk）抑制剂，显示出对激酶介导的IgG Fcγ受体信号转导的功效。

库存：现货

规格	价格	数量
2 mg	￥ 350.00
5 mg	￥ 560.00
10 mg	￥ 980.00
25 mg	￥ 1,960.00
10mM * 1mL in DMSO	￥ 840.00

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生物活性

R788 (Fostamatinib)是重要的脾酪氨酸激酶（Syk）抑制剂，显示出对激酶介导的IgG Fcγ受体信号转导的功效。

靶点信息

Syk	Adenosine A3 receptor	Adenosine transporter	Monoamine transporter
41 nM	81 nM	1.84 μM	2.74 μM

溶解度 *

In vitro (25°C)	DMSO	107 mg/mL (184.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.23 mL	86.13 mL	172.27 mL
0.5 mM	3.45 mL	17.23 mL	34.45 mL
1 mM	1.72 mL	8.61 mL	17.23 mL
5 mM	0.34 mL	1.72 mL	3.45 mL

*The above data is based on the productmolecular weight 580.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11926
作用机制	Inhibitor (抑制剂)
M. Wt	580.5
Formula	C23H26FN6O9P
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	901119-35-5
Synonyms	R-788
SMILES	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C