Ramelteon (TAK-375)

Name: Ramelteon (TAK-375)
SKU: A10777

目录号: A10777

MT1/MT2-Receptor 激动剂

Ramelteon (TAK-375) Chemical Structure

CAS NO. 196597-26-9

Ramelteon (TAK-375)是melatonin受体激动剂，对褪黑激素MT1（IC50 = 28.5±8.55 pM）和MT2（20.1±9.25 pM）受体均具有高亲和力，并且相对于MT3受体具有选择性。

库存：现货

规格	价格	数量
5 mg	￥ 476.00
10 mg	￥ 812.00
25 mg	￥ 1,428.00
50 mg	￥ 2,380.00
10mM * 1mL in DMSO	￥ 742.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

Ramelteon (TAK-375)是melatonin受体激动剂，对褪黑激素MT1（IC50 = 28.5±8.55 pM）和MT2（20.1±9.25 pM）受体均具有高亲和力，并且相对于MT3受体具有选择性。

靶点信息

MT1 receptor	MT receptor (chicken)	MT2 receptor
14 pM(Ki)	23.1 pM(Ki)	112 pM(Ki)

溶解度 *

In vitro (25°C)	DMSO	47 mg/mL (181.22 mM)
	Water	Insoluble
	Ethanol	47 mg/mL (181.22 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.57 mL	192.83 mL	385.65 mL
0.5 mM	7.71 mL	38.57 mL	77.13 mL
1 mM	3.86 mL	19.28 mL	38.57 mL
5 mM	0.77 mL	3.86 mL	7.71 mL

*The above data is based on the productmolecular weight 259.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10777
作用机制	Agonist (激动剂)
M. Wt	259.3
Formula	C16H21NO2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	196597-26-9
Synonyms	Rozerem, TAK-375, TAK375
SMILES	CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3