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Raxatrigine (GSK1014802)是一种新型的钠通道阻滞剂，是一种有效的抗惊厥药物。在大鼠中，GSK1014802（20-80 mg/kg p.o.）以剂量依赖的方式减轻了苯环利定（PCP）诱导的逆向学习障碍，这表明GSK1014802在治疗精神分裂症的认知潜力方面具有潜力。 GSK2还是人MAO-B的有效抑制剂，pIC50值为7.96，但不抑制人MAO-A。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.81 mL | 159.06 mL | 318.12 mL |
| 0.5 mM | 6.36 mL | 31.81 mL | 63.62 mL |
| 1 mM | 3.18 mL | 15.91 mL | 31.81 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
*The above data is based on the productmolecular weight 314.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13020 |
|---|---|
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 314.35 |
| Formula | C18H19FN2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 934240-30-9 |
| Synonyms | GSK1014802, GSK-1014802, GSK 1014802 |
| SMILES | FC1=CC=CC=C1COC2=CC=C([C@@](N3)([H])CC[C@@]3([H])C(O)=N)C=C2 |
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