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￥ 0.00 Protein Tyrosine Kinases
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IRAK inhibitor 6 (IRAK-IN-6)
Catalog No. A11460 IRAK 抑制剂IRAK-IN-6，也称为IRAK抑制剂6，是白介素1受体相关激酶4（IRAK-4）抑制剂。 据报道，IRAK-4对于激活包括NF-kB和MAPK途径在内的细胞内信号级联反应至关重要，这对于炎症细胞因子的产生至关重要。 了解更多 -
AS 2444697
Catalog No. A17186 -
GSK 2250665A
Catalog No. A17191 Itk 抑制剂GSK-2250665A是pKi = 9.2的Itk抑制剂，它对Aurora B激酶和Btk（pIC50值分别为6.4和6.5）和一组其他激酶表现出对Itk的选择性。 抑制PBMC中IFNγ的产生。 了解更多 -
PF 06465469
Catalog No. A17190 -
ITK inhibitor 2
Catalog No. A19096 ITK inhibitorITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2 nM. 了解更多 -
BMS-509744
Catalog No. A11319 -
UNC2881
Catalog No. A14276 -
R428
Catalog No. A13741 -
TP-0903
Catalog No. A15776 -
SGI-7079
Catalog No. A15864 -
JNJ-28312141
Catalog No. A12687 CSF1R 抑制剂JNJ-28312141是一种口服活性CSF1R抑制剂（Colony-stimulating factor-1受体，CRF1R），也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达，是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。 了解更多 -
JTE-952
Catalog No. A18391 CSF-1R 抑制剂TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. 了解更多 -
c-Fms-IN-8
Catalog No. A18879 CSF-1R, c-FMS Type II inhibitorc-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. 了解更多 -
Edicotinib
Catalog No. A13008 CSF-1 receptor inhibitorEdicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease. 了解更多 -
GENZ-882706
Catalog No. A12484 CSF-1R InhibitorGENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1. 了解更多 -
GW2580
Catalog No. A11959 -
AZ 23
Catalog No. A12666 -
Sitravatinib (MGCD516)
Catalog No. A16259 -
ANA-12
Catalog No. A13877 -
LOXO-101 (ARRY-470, Larotrectinib)
Catalog No. A15974 -
GW 441756
Catalog No. A16238 -
LOXO-101 sulfate
Catalog No. A16239 TRK 抑制剂LOXO-101 sulfate是一种小分子，设计用于阻断TRK家族的ATP结合位点，对TRKA，TRKB和TRKC激酶具有2至20 nM的细胞效力。 了解更多 -
Tyrosine kinase inhibitor
Catalog No. A15267 Tyrosine kinase 抑制剂Tyrosine kinase inhibitor是一种抑制酪氨酸激酶的药物。酪氨酸激酶是负责通过信号转导级联反应激活许多蛋白质的酶。 了解更多 -
Tie2 kinase inhibitor
Catalog No. A10932 -
Pexmetinib (ARRY-614)
Catalog No. A10895 p38 MAPK 抑制剂Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶（MAPK）和Tie2/Tek受体酪氨酸激酶，其在HEK-293细胞中的IC50分别为4 nM/18 nM。Pexmetinib是一种有效的细胞因子合成抑制剂。 了解更多 -
PLX647
Catalog No. A15519 -
AZD3229 Tosylate
Catalog No. A16867
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