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RepSox (SJN 2511)是TGF-βI型受体ALK5的选择性抑制剂（ALK5自磷酸化和ALK5结合的IC50值分别为0.004和0.023μM）。
靶点信息
| TGFβR1(ALK5) (Cell-free assay) | ||||
| 4 nM |
| In vitro | DMSO | 49 mg/mL (170.54 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.8 mL | 174.02 mL | 348.04 mL |
| 0.5 mM | 6.96 mL | 34.8 mL | 69.61 mL |
| 1 mM | 3.48 mL | 17.4 mL | 34.8 mL |
| 5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
*The above data is based on the productmolecular weight 287.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11762 |
|---|---|
| M. Wt | 287.32 |
| Formula | C17H13N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 446859-33-2 |
| Synonyms | E-616452, SJN 2511, ALK 5 inhibitor |
| SMILES | CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4 |
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