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Rilpivirine (R 278474,TMC 278)是第二代非核苷逆转录酶抑制剂（NNRTI），与较老的NNRTIs（例如依非韦伦）相比，具有更高的效力，更长的半衰期和更低的副作用。
| In vitro | DMSO | 66 mg/mL (180.12 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.29 mL | 136.46 mL | 272.93 mL |
| 0.5 mM | 5.46 mL | 27.29 mL | 54.59 mL |
| 1 mM | 2.73 mL | 13.65 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11542 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 366.4 |
| Formula | C22H18N6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 500287-72-9 |
| Synonyms | R278474, TMC278, TMC-278 |
| SMILES | CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N |
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