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Riluzole (Rilutek)阻断与受损神经元有关的TTX敏感性钠通道，从而减少钙离子的流入并间接防止谷氨酸受体的刺激。
靶点信息
| Sodium channel | NMDA receptor | Glutamate release | ||
| In vitro | DMSO | 42 mg/mL (179.33 mM) | |
| Water | Insoluble | ||
| Ethanol | 42 mg/mL (179.33 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.7 mL | 213.49 mL | 426.99 mL |
| 0.5 mM | 8.54 mL | 42.7 mL | 85.4 mL |
| 1 mM | 4.27 mL | 21.35 mL | 42.7 mL |
| 5 mM | 0.85 mL | 4.27 mL | 8.54 mL |
*The above data is based on the productmolecular weight 234.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10795 |
|---|---|
| M. Wt | 234.2 |
| Formula | C8H5F3N2OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1744-22-5 |
| Synonyms | PK-26124, RP-54274, Rilutek |
| SMILES | C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N |
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