RIP Kinase

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  1. Nec-4

    Catalog No. A21033
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    RIP1 inhibitor
    Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM. 了解更多
  2. RIPK1-IN-4

    Catalog No. A21029
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    RIP1 kinase inhibitor
    RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase. 了解更多
  3. WEHI-345

    Catalog No. A21012
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    RIPK2 inhibitor
    WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. 了解更多
  4. RIPA-56

    Catalog No. A12473
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    RIP1 inhibitor
    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. 了解更多
  5. RIPK1-IN-7

    Catalog No. A18940
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    RIPK1 inhibitor
    RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. 了解更多
  6. RIPK1-IN-3

    Catalog No. A19023
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    RIPK1 inhibitor
    RIPK1-IN-3 (Example 38), a RIPK1 inhibitor, extracted from patent WO2018148626A1, possesses anti-inflammatory proprieties. 了解更多
  7. GSK547

    Catalog No. A19073
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    RIP1 inhibitor
    GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. 了解更多
  8. GSK2982772

    Catalog No. A19380
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    RIP1 kinase inhibitor
    GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. 了解更多
  9. GSK3145095

    Catalog No. A19427
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    RIP1 kinase inhibitor
    GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM . 了解更多
  10. GSK-843

    Catalog No. A18526
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    RIPK3 inhibitor
    GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. 了解更多
  11. PK68

    Catalog No. A18582
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    RIPK1 inhibitor
    PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. 了解更多
  12. HS-1371

    Catalog No. A18653
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    RIP3 inhibitor
    HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8?nM. 了解更多
  13. GSK963

    Catalog No. A18346
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    RIP1 kinase inhibitor
    GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro. 了解更多
  14. RIP2 kinase inhibitor 2

    Catalog No. A16313
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    RIP2 kinase 抑制剂
    RIP2 kinase inhibitor 2 是从专利WO/2014043437 A1(化合物实施例9)中提取的受体相互作用蛋白2(RIP2)激酶抑制剂。 了解更多
  15. RIP2 kinase inhibitor 1

    Catalog No. A16312
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    RIP2 kinase 抑制剂
    RIP2 kinase inhibitor 1 是从专利WO/2014043446 A1(化合物实施例1)中提取的受体相互作用蛋白2(RIP2)激酶抑制剂。 了解更多
  16. GSK583

    Catalog No. A16311
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    RIP2 kinase 抑制剂
    GSK583是RIP2激酶的高效抑制剂。 了解更多
  17. GSK481

    Catalog No. A12615
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    RIP1 抑制剂
    GSK481是新型的RIP1抑制剂苯并a庚酮(BOAz)系列。受体相互作用蛋白激酶1(RIP1)已被认为是通过调节程序性坏死调节炎症的关键因素。已显示对该激酶的抑制作用可阻止细胞坏死,从而将RIP1确定为潜在治疗多种炎性疾病的可行靶标。 了解更多
  18. Necrostatin-1

    Catalog No. A11973
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    RIPK1 抑制剂
    Necrostatin-1是一种与ATP竞争的,与受体相互作用的蛋白激酶1(RIPK1)的变构抑制剂(EC50 = 182 nM)。 了解更多

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