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DNA Damage /
RNA/DNA Polymerase

RNA/DNA Polymerase

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dmDNA31

Catalog No. A18469
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DNA-dependent RNA polymerase 抑制剂

dmDNA31 is a rifamycin-class antibiotic that inhibits bacterial DNA-dependent RNA polymerase with potent bactericidal activity against S. aureus. 了解更多

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ddATP

Catalog No. A18898
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DNA polymerase 抑制剂

dATP is a dideoxynucleotide, acts as a chain-elongating inhibitor of DNA polymerase, used for Sanger method for DNA sequencing. 了解更多

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DNA31

Catalog No. A18466
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RNA polymerase 抑制剂

DNA31 is a potent RNA polymerase inhibitor. 了解更多

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Pseudouridimycin

Catalog No. A18520
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RNA polymerase 抑制剂

Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria. 了解更多

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ACX-362E

Catalog No. A18560
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DNA polymerase IIIC 抑制剂

ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens. 了解更多

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Thiolutin

Catalog No. A15386
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RNA polymerase 抑制剂

Thiolutin是一种RNA聚合酶抑制剂，是链霉菌属细菌产生的一种基于硫的微生物抗生素。了解更多

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Mithramycin A

Catalog No. A15385
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DNA/RNA polymerase 抑制剂

Mithramycin A是一种抗生素DNA/RNA聚合酶和可与DNA结合的转录抑制剂，可促进TNF-α的表达。Fas-配体诱导细胞凋亡。了解更多

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Oncrasin 1

Catalog No. A15333
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RNA polymerase II 抑制剂

Oncrasin 1是一种促凋亡物质。诱导PKC1的异常核聚集并抑制。了解更多

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Valaciclovir

Catalog No. A15270
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DNA polymerase 抑制剂

Valaciclovir是一种抗病毒药，用于治疗单纯疱疹，带状疱疹和B型疱疹。了解更多

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BMH-21

Catalog No. A14335
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RNA polymerase 抑制剂

BMH-21是有效的小分子DNA嵌入剂。BMH-21结合核糖体DNA并抑制RNA聚合酶I转录。了解更多

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- Masahiko Okuda, .et al. Three human RNA polymerases interact with TFIIH via a common RPB6 subunit, Nucleic Acids Res, 2021, Jul 16 PMID: 34268577
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Delavirdine mesylate

Catalog No. A13274
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NNRT 抑制剂

Delavirdine是一种有效的人类免疫缺陷病毒1型（HIV-1）逆转录酶（RT）抑制剂。了解更多

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Abacavir

Catalog No. A11115
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Transcriptase 抑制剂

Abacavir是一种核苷类似物逆转录酶抑制剂（NRTI）；鸟苷类似物用于治疗艾滋病毒和艾滋病。了解更多

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Abacavir sulfate

Catalog No. A11120
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Transcriptase 抑制剂

Abacavir sulfate是一种核苷类似物逆转录酶抑制剂（NRTI）。了解更多

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Tenofovir (Viread)

Catalog No. A10908
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HIV reverse transcriptase 抑制剂

Tenofovir (Viread)属于一类称为核苷逆转录酶抑制剂（NRTIs）的药物。它通过减少血液中的HIV含量起作用。了解更多

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T-705 (Favipiravir)

Catalog No. A11590
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viral RNA polymerase 抑制剂

T-705 (Favipiravir)是一种有效的选择性RNA-dependent RNA polymerase抑制剂，在体外和体内均表现出有效的抗流感病毒活性。了解更多

Product Citations (9)

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- Satoko Yamaoka, .et al. Development of accelerated high-throughput antiviral screening systems for emerging orthomyxoviruses, Antiviral Res, 2022, Apr;200:105291 PMID: 35296419
- Crystal A Mendoza, .et al. The NF- κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses, Antiviral Res, 2021, Jan;185:104993 PMID: 33296695
- Liva Checkmahomed, .et al. In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses, Viruses, 2020, Oct; 12(10): 1139 PMID: 33049959
- JE Comer, .et al. Filovirus Virulence in Interferon α,β and γ Double Knockout Mice, and Treatment with Favipiravir, Viruses, 2019, Feb 3;11(2). pii: E137 PMID: 30717492
- Ma J, .et al. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo, Antiviral Res, 2018, Feb;150:112-122 PMID: 29253498
- Ji-Ae Kim, .et al. Favipiravir and Ribavirin Inhibit Replication of Asian and African Strains of Zika Virus in Different Cell Models, Viruses, 2018, Feb; 10(2): 72 PMID: 29425176
- Haejin Chun, .et al. Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment, Polym Chem, 2018, 9: 2116-2123
- Baz M, .et al. Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus, Viruses, 2018, Nov 3;10(11) PMID: 30400276
- Sehee Park, .et al. Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice, PLoS One., 2014, 9(7): e101325 PMID: 24992479
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Rifampin

Catalog No. A10791
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RNA polymerase 抑制剂

Rifampin是DNA依赖性的RNA聚合酶抑制剂，孕烷X受体（PXR）的原型激活剂。了解更多

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- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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Rifabutin

Catalog No. A10790
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RNA polymerase 抑制剂

Rifabutin是一种主要用于治疗肺结核的杀菌抗生素。它的作用是基于阻断细菌的DNA依赖性RNA聚合酶。了解更多

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- Matt D Johansen, .et al. Rifabutin is bactericidal against intracellular and extracellular forms of Mycobacterium abscessus, Antimicrob Agents Chemother, 2020, Aug 17;AAC.00363-20 PMID: 32816730
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
- Dinah Binte Aziz, .et al. Rifabutin Is Active against Mycobacterium abscessus Complex, Antimicrob Agents Chemother, 2017, Jun; 61(6): e00155-17 PMID: 28396540
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Dehydroaltenusin

Catalog No. A21804
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eukaryotic DNA polymerase α inhibitor

Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. 了解更多

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