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RO4987655是一种口服活性小分子，靶向有丝分裂原激活的蛋白激酶激酶1（MAP2K1或MEK1），抑制 MEK1/MEK2，IC50 为 5.2 nM。具有潜在的抗肿瘤活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.69 mL | 88.45 mL | 176.9 mL |
| 0.5 mM | 3.54 mL | 17.69 mL | 35.38 mL |
| 1 mM | 1.77 mL | 8.85 mL | 17.69 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.54 mL |
*The above data is based on the productmolecular weight 565.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13272 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 565.28 |
| Formula | C20H19F3IN3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 874101-00-5 |
| Synonyms | RO-4987655, RO 4987655 |
| SMILES | C1CC(=O)N(OC1)CC2=C(C(=C(C(=C2)C(=O)NOCCO)NC3=C(C=C(C=C3)I)F)F)F |
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