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RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.3 mL | 81.5 mL | 163 mL |
| 0.5 mM | 3.26 mL | 16.3 mL | 32.6 mL |
| 1 mM | 1.63 mL | 8.15 mL | 16.3 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
*The above data is based on the productmolecular weight 613.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20865 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 613.51 |
| Formula | C31H31Cl2FN4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1309684-94-3 |
| Synonyms | RO 8994, RO-8994 |
| SMILES | O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)NC5=CC=C(C(N)=O)C=C5OC |
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