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Romidepsin (FK228 ,Depsipeptide)

Romidepsin (FK228 ,Depsipeptide)

Name: Romidepsin (FK228 ,Depsipeptide)
SKU: A11920

目录号: A11920

HDAC 抑制剂

Product Citations (7)

Romidepsin (FK228 ,Depsipeptide) Chemical Structure

CAS NO. 128517-07-7

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2，IC50分别为1.6 nM和3.9 nM，但相对较弱地分别抑制HDAC4和HDAC6，IC50值为25 nM和79 nM。

库存：现货

规格	价格	数量
1 mg	￥ 700.00
2 mg	￥ 1,120.00
5 mg	￥ 1,890.00
10 mg	￥ 3,500.00

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生物活性

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2，IC50分别为1.6 nM和3.9 nM，但相对较弱地分别抑制HDAC4和HDAC6，IC50值为25 nM和79 nM。

靶点信息

HDAC1 (Cell-free assay)	HDAC2 (Cell-free assay)
36 nM	47 nM

溶解度 *

In vitro (25°C)	DMSO	9 mg/mL (16.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5%Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.49 mL	92.47 mL	184.95 mL
0.5 mM	3.7 mL	18.49 mL	36.99 mL
1 mM	1.85 mL	9.25 mL	18.49 mL
5 mM	0.37 mL	1.85 mL	3.7 mL

*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11920
作用机制	Inhibitor (抑制剂)
M. Wt	540.7
Formula	C24H36N4O6S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	128517-07-7
SMILES	C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C