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Rosiglitazone (BRL-49653)

Rosiglitazone (BRL-49653)

Name: Rosiglitazone (BRL-49653)
SKU: A10807

目录号: A10807

PPAR 激动剂

Rosiglitazone (BRL-49653) Chemical Structure

CAS NO. 122320-73-4

Rosiglitazone (BRL-49653)是有效的降糖药，也是有效的噻唑烷二酮类胰岛素增敏剂，在大鼠，3T3-L1和人体脂肪细胞中IC50分别为12，4和9 nM。Rosiglitazone是PPAR-gamma的配体，对PPAR-alpha没有结合力。

库存：现货

规格	价格	数量
25 mg	￥ 280.00
50 mg	￥ 350.00
100 mg	￥ 700.00
200 mg	￥ 1,050.00
10mM * 1mL in DMSO	￥ 350.00

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产品详情

生物活性

靶点信息

PPAR (Cell-free assay)

溶解度 *

In vitro (25°C)	DMSO	65 mg/mL (181.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.98 mL	139.9 mL	279.8 mL
0.5 mM	5.6 mL	27.98 mL	55.96 mL
1 mM	2.8 mL	13.99 mL	27.98 mL
5 mM	0.56 mL	2.8 mL	5.6 mL

*The above data is based on the productmolecular weight 357.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10807
作用机制	Agonist (激动剂)
M. Wt	357.4
Formula	C18H19N3O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	122320-73-4
Synonyms	Avandia, BRL-49653
SMILES	CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3