产品详情

生物活性

RTA-408是一种合成的三萜类化合物，可有效激活抗氧化转录因子Nrf2并抑制促炎转录因子NF-kB。

靶点信息

Nrf2

溶解度 *

In vitro (25°C)	DMSO	98 mg/mL (176.66 mM)
	Water	Insoluble
	Ethanol	20 mg/mL (36.05 mM)
In vivo	10%DMSO+90% Corn oil	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.03 mL	90.14 mL	180.27 mL
0.5 mM	3.61 mL	18.03 mL	36.05 mL
1 mM	1.8 mL	9.01 mL	18.03 mL
5 mM	0.36 mL	1.8 mL	3.61 mL

*The above data is based on the productmolecular weight 554.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14417
作用机制	Inhibitor (抑制剂)
M. Wt	554.71
Formula	C33H44F2N2O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1474034-05-3
Synonyms	RTA 408, RTA408
SMILES	C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)NC(=O)C(C)(F)F