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S/GSK1349572 (Dolutegravir)

S/GSK1349572 (Dolutegravir)

Name: S/GSK1349572 (Dolutegravir)
SKU: A11068

目录号: A11068

HIV integrase 抑制剂

Product Citations (1)

S/GSK1349572 (Dolutegravir) Chemical Structure

CAS NO. 1051375-16-6

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。

库存：现货

规格	价格	数量
5 mg	￥ 525.00
10 mg	￥ 875.00
50 mg	￥ 2,205.00
100 mg	￥ 3,465.00
10mM * 1mL in DMSO	￥ 840.00

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生物活性

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。

靶点信息

HIV integrase (Cell-free assay)
2.7 nM

溶解度 *

In vitro	DMSO	Warmed: 71 mg/mL (169.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.84 mL	119.22 mL	238.44 mL
0.5 mM	4.77 mL	23.84 mL	47.69 mL
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL

*The above data is based on the productmolecular weight 419.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11068
作用机制	Inhibitor (抑制剂)
M. Wt	419.4
Formula	C20H19F2N3O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1051375-16-6
Synonyms	Dolutegravir, GSK-1349572
SMILES	C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O