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GPCR / G Protein /
S1P Receptor

S1P Receptor

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PF429242 dihydrochloride

Catalog No. A21386
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S1P inhibitor

PF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM. 了解更多

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FTY720 (S)-Phosphate

Catalog No. A21324
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S1PR1 agonist

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. 了解更多

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Cenerimod

Catalog No. A20913
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S1P1 agonist

Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. 了解更多

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TY-52156

Catalog No. A12265
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S1P3 receptor antagonist

TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM. 了解更多

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VPC 23019

Catalog No. A20102
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S1P antagonist

VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). 了解更多

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MP-A08

Catalog No. A16290
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ATP competitive SK 抑制剂

MP-A08是一种高度选择性的ATP竞争性SK抑制剂，其靶向SK1和SK2的Kivalue分别为6.9±0.8 uM和27±3 uM。了解更多

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K145 hydrochloride

Catalog No. A16289
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SphK2 抑制剂

K145 hydrochloride是选择性鞘氨醇激酶2（SphK2）抑制剂和抗癌剂。了解更多

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K145

Catalog No. A16288
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SphK2 抑制剂

K145是一种选择性SphK2抑制剂，IC50为4.30±0.06μM，而在浓度不超过10 uM时，对SphK1无抑制作用。了解更多

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Ponesimod

Catalog No. A13307
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S1P1 receptor modulator

Ponesimod是一种口服活性，选择性鞘氨醇-1-磷酸受体1（S1P1）免疫调节剂，EC50为5.7 nM。了解更多

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SKI-II

Catalog No. A15988
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SphK 抑制剂

SKI-II是鞘氨醇激酶的选择性非脂质抑制剂（IC50 = 0.5 uM）。了解更多

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NS13001

Catalog No. A15833
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SK2 modulator

NS13001是选择性的SK2/3调节剂，可作为治疗SCA2和其他可能的小脑共济失调的潜在治疗剂。了解更多

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RPC1063 (Ozanimod)

Catalog No. A15819
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S1PR1 modulators

RPC1063 (Ozanimod)是选择性的鞘氨醇1磷酸酯受体调节剂和方法，可用于治疗与S1P1-β相关的疾病。了解更多

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PF-543 Citrate

Catalog No. A15210
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SphK1 抑制剂

PF-543 Citrate是一种新型的SphK1细胞渗透抑制剂，K（i）为3.6 nM，PF-543具有鞘氨醇竞争性，对SphK1的选择性是SphK2同种型的100倍以上。了解更多

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KRP-203

Catalog No. A13308
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S1PR1 抑制剂

KRP-203是选择性鞘氨醇-1-磷酸受体激动剂。它表明减少大鼠移植模型中外周淋巴细胞的浸润并延长生存期。了解更多

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Fingolimod

Catalog No. A17798
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S1P antagonist

Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. 了解更多

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ASP1126

Catalog No. A18432
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S1P agonist

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. 了解更多

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CYM 5442 HCl

Catalog No. A13637
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EDG-1 (S1P1) 激动剂

CYM 5442 HCl是一种有效的体外选择性EDG-1（S1P1）激动剂（EC50 = 1.35 nM）。了解更多

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ABC294640

Catalog No. A12614
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SphK2 抑制剂

ABC294640是一种口服的芳基金刚烷化合物，是鞘氨醇激酶2（SK2）的选择性抑制剂，Ki 为 9.8 μM，具有潜在的抗肿瘤活性。了解更多

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PF-543

Catalog No. A13039
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SphK1 抑制剂

PF-543是一种新型选择性SK-1抑制剂，可与鞘氨醇竞争性抑制SK-1活性。了解更多

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BAF312 (Siponimod)

Catalog No. A12906
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S1PR1/S1PR5 抑制剂

BAF312 (Siponimod)是下一代有效的1-磷酸鞘氨醇（S1P）受体激动剂，对S1P1和S1P5具有选择性。了解更多

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FTY720 (Fingolimod)

Catalog No. A10408
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S1P Receptor 拮抗剂

FTY720 (Fingolimod)是ISP-1(肉豆蔻酸)的衍生物，ISP-1是中国草药Iscaria sinclarii的真菌代谢物，也是鞘氨醇的结构类似物。了解更多

Product Citations (5)

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- Tina Sepasi, .et al. Targeted gene delivery to the brain using CDX-modified chitosan nanoparticles, BioImpacts, 2022, 28 May
- Zengzi Zhou, .et al. Effects of immunomodulatory drug Fingolimod (FTY720) on Chlamydia dissemination and pathogenesis, Infect Immun, 2020, Oct 19;88(11):e00281-20 PMID: 32868341
- Mayu Idehara, .et al. Inulooligosaccharides in Atractylodis lanceae rhizoma and Atractylodis rhizoma of hochuekkito formula are essential for regulation of the pulmonary immune system of immuno-compromised mice, Traditional & Kampo Medicine, 2020, 22 July
- Luwa Yuan, .et al. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking, Sci Rep, 2019, 9:11156 PMID: 31371790
- Sakai Y, .et al. Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system, Int J Biol Macromol, 2018, Nov 22;124:505-514 PMID: 30471397

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