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SAR245409 (XL765,Voxtalisib)是PI3K/mTOR双激酶抑制剂XL765是口服生物可利用的小分子，靶向PI3K/mTOR信号途径中的磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）激酶的哺乳动物靶标，具有潜在的抗肿瘤活性。
Targets
| Target | Value |
|---|---|
| PI3Kγ | IC50: 9nM |
| PI3Kα | IC50: 39nM |
| PI3Kδ | IC50: 43nM |
| PI3Kβ | IC50: 113nM |
| DNA-PK | IC50: 150nM |
| mTOR | IC50: 157nM |
| In vitro | DMSO | 53 mg/mL (196.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 184.99 mL | 369.97 mL |
| 0.5 mM | 7.4 mL | 37 mL | 73.99 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
*The above data is based on the productmolecular weight 270.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16276 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 270.29 |
| Formula | C13H14N6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 934493-76-2 |
| Synonyms | Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765 |
| SMILES | O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC |
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