SB 431542

Name: SB 431542
SKU: A10826

目录号: A10826

TGF-beta/Smad 抑制剂

Product Citations (3)

SB 431542 Chemical Structure

CAS NO. 301836-41-9

SB 431542是转化生长因子-β超家族I型激活素受体样激酶（ALK）受体ALK4，ALK5和ALK7的有效抑制剂。

库存：现货

规格	价格	数量
10 mg	￥ 560.00
25 mg	￥ 1,120.00
50 mg	￥ 2,100.00
100 mg	￥ 3,920.00
10mM * 1mL in DMSO	￥ 560.00

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生物活性

SB 431542是转化生长因子-β超家族I型激活素受体样激酶（ALK）受体ALK4，ALK5和ALK7的有效抑制剂。

靶点信息

ALK4 (Cell-free assay)	ALK7 (Cell-free assay)	ALK5 (Cell-free assay)
N/A		94 nM

溶解度 *

In vitro (25°C)	DMSO	75 mg/mL (195.11 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (7.8 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.01 mL	130.07 mL	260.15 mL
0.5 mM	5.2 mL	26.01 mL	52.03 mL
1 mM	2.6 mL	13.01 mL	26.01 mL
5 mM	0.52 mL	2.6 mL	5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10826
作用机制	Inhibitor (抑制剂)
M. Wt	384.4
Formula	C22H16N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	301836-41-9
Synonyms	SB-431542, SB431542
SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5