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SB939 (Pracinostat)是HDAC的口服抑制剂，对I，II和IV类HDAC具有选择性，在体外HDAC1活性测定中显示IC50值为77 nM。
Targets
| Target | Value |
|---|---|
| HDAC10 | IC50: 40nM |
| HDAC3 | IC50: 43nM |
| HDAC5 | IC50: 47nM |
| HDAC1 | IC50: 49nM |
| HDAC4 | IC50: 56nM |
| HDAC9 | IC50: 70nM |
| HDAC11 | IC50: 93nM |
| HDAC2 | IC50: 96nM |
| HDAC7 | IC50: 137nM |
| HDAC8 | IC50: 140nM |
| HDAC6 | IC50: 1.008μM |
| SIRT1 | IC50: >100μM |
| In vitro (25°C) | DMSO | 68 mg/mL (189.68 mM) | |
| Water | Insoluble | ||
| Ethanol | 26 mg/mL (72.52 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.89 mL | 139.47 mL | 278.94 mL |
| 0.5 mM | 5.58 mL | 27.89 mL | 55.79 mL |
| 1 mM | 2.79 mL | 13.95 mL | 27.89 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
*The above data is based on the productmolecular weight 358.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10830 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 358.5 |
| Formula | C20H30N4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 929016-96-6 |
| Synonyms | Pracinostat, SB-939 |
| SMILES | CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO |
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