产品详情

生物活性

SD-208是一种有效的ATP竞争性转化生长因子-β受体1（TGF-βRI）抑制剂（IC50 = 49 nM）；与TGF-βRII和其他常见激酶相比，分别显示出> 100倍和> 17倍的选择性。

靶点信息

TGF-βRI (ALK5)
48 nM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 8 mg/mL (22.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% methylcellulose	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.35 mL	141.74 mL	283.49 mL
0.5 mM	5.67 mL	28.35 mL	56.7 mL
1 mM	2.83 mL	14.17 mL	28.35 mL
5 mM	0.57 mL	2.83 mL	5.67 mL

*The above data is based on the productmolecular weight 352.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14066
作用机制	Inhibitor (抑制剂)
M. Wt	352.75
Formula	C17H10ClFN6
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	627536-09-8
Synonyms	SD 208, SD208
SMILES	C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F