Seletalisib (UCB-5857)

Name: Seletalisib (UCB-5857)
SKU: A16797

目录号: A16797

PI3K 抑制剂

Seletalisib (UCB-5857) Chemical Structure

CAS NO. 1362850-20-1

Seletalisib (UCB-5857)是一种新型的PI3Kδ小分子抑制剂，其IC50值为12 nM，相对于其他I类PI3K亚型（介于24-303倍之间），对PI3Kδ具有显著的选择性。

库存：现货

规格	价格	数量
2 mg	￥ 840.00
5 mg	￥ 1,540.00
25 mg	￥ 4,200.00

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生物活性

Seletalisib (UCB-5857)是一种新型的PI3Kδ小分子抑制剂，其IC50值为12 nM，相对于其他I类PI3K亚型（介于24-303倍之间），对PI3Kδ具有显著的选择性。

溶解度 *

In vitro	DMSO	89 mg/mL (184.32 mM)
	Water	Insoluble
	Ethanol	89 mg/mL (184.32 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.71 mL	103.55 mL	207.1 mL
0.5 mM	4.14 mL	20.71 mL	41.42 mL
1 mM	2.07 mL	10.36 mL	20.71 mL
5 mM	0.41 mL	2.07 mL	4.14 mL

*The above data is based on the productmolecular weight 482.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16797
作用机制	Inhibitor (抑制剂)
M. Wt	482.85
Formula	C23H14ClF3N6O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1362850-20-1
Synonyms	UCB-5857; UCB 5857; UCB5857; Seletalisib
SMILES	FC(F)(F)[C@@H](C1=CC2=CC=CC(Cl)=C2N=C1C3=CC=C[N+]([O-])=C3)NC4=C5C(C=CC=N5)=NC=N4