Serine Protease
Catalog No. | Inhibitor Name | Serine Protease | Other |
---|---|---|---|
A14263 | Aprotinin | *** | Thrombin,Trypsin,kallikrein |
A12779 | Alvelestat (AZD9668) | **** | |
A10617 | Nafamostat Mesylate | ||
A11901 | PMSF | cysteine protease | |
A14145 | Leupeptin Hemisulfate | Cysteine protease | |
A14270 | AEBSF HCl |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Nafamostat
Catalog No. A20827 serine protease inhibitorNafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. 了解更多 -
Nafamostat hydrochloride
Catalog No. A20828 serine protease inhibitorNafamostat hydrochloride is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. 了解更多 -
Fumonisin B1
Catalog No. A15379 serine/threonine phosphatase 抑制剂Fumonisin B1是由镰孢镰刀菌(Fusarium moniliforme)产生的真菌代谢产物,已显示可抑制蛋白质丝氨酸/苏氨酸磷酸酶(PP1,PP2A,PP2B,PP2C和PP5/T/K/H),并且对PP5最有效。 了解更多 -
Sivelestat sodium hydrate (ONO-5046 sodium hydrate)
Catalog No. A16137 Neutrophil elastase 抑制剂Sivelestat sodium hydrate (ONO-5046 sodium hydrate)是人嗜中性粒细胞弹性蛋白酶的竞争性抑制剂,还抑制从兔,大鼠,仓鼠和小鼠获得的白细胞弹性蛋白酶。 了解更多 -
PMSF
Catalog No. A11901 -
SSR 69071
Catalog No. A15315 -
Sivelestat
Catalog No. A14184 Neutrophil elastase 抑制剂Sivelestat是一种可渗透细胞的磺酰苯胺化合物,可作为中性粒细胞弹性蛋白酶的强效,底物竞争性和高度特异性抑制剂(大鼠,兔,仓鼠,人类和小鼠白细胞弹性蛋白酶的IC50 = 19-49 nM)。 了解更多 -
AEBSF HCl
Catalog No. A14270 -
Leupeptin hemisulfate
Catalog No. A14145 -
Alvelestat
Catalog No. A12779 neutrophil elastase 抑制剂Avelestat,也称为AZD9668,是可口服的,高度选择性neutrophil elastase (NE)抑制剂,IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。 了解更多 -
Sivelestat sodium salt
Catalog No. A14073 Neutrophil elastase 抑制剂Sivelestat sodium salt是一种选择性白细胞弹性蛋白酶抑制剂(IC50 = 44 nM),在一系列其他蛋白酶中均无活性。它在体外抑制NF-κB活化和LTB4诱导的中性粒细胞转运。 了解更多 -
Camostat mesylate
Catalog No. A11764 Camostat mesylate是胰蛋白酶样的蛋白酶抑制剂,抑制胰蛋白酶和各种炎症性蛋白酶,包括纤溶酶,激肽释放酶和凝血酶。 了解更多 -
BCX 1470 methanesulfonate
Catalog No. A11325 Serine protease 抑制剂BCX 1470 methanesulfonate是丝氨酸蛋白酶抑制剂。BCX 1470在体外阻断补体酶CLs和因子D的酯酶和溶血活性。 了解更多 -
BCX 1470
Catalog No. A11331 -
Nafamostat mesylate
Catalog No. A10617 serine protease 抑制剂Nafamostat mesylate是一种抗凝剂。广谱丝氨酸蛋白酶抑制剂。在哮喘小鼠模型中减少嗜酸性粒细胞浸润,肥大细胞活化和气道反应性。 了解更多