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SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
| In vitro | DMSO | 68 mg/mL (185.48 mM) | |
| Water | Insoluble | ||
| Ethanol | 17 mg/mL (46.36 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.28 mL | 136.39 mL | 272.78 mL |
| 0.5 mM | 5.46 mL | 27.28 mL | 54.56 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.28 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18463 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 366.6 |
| Formula | C21H38N2OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2374313-54-7 |
| Synonyms | SIS-17; SIS 17; SIS17; |
| SMILES | O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC |
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