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SLx-2119 (KD025)

SLx-2119 (KD025)

Name: SLx-2119 (KD025)
SKU: A15239

目录号: A15239

ROCK2 抑制剂

SLx-2119 (KD025) Chemical Structure

CAS NO. 911417-87-3

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。

库存：现货

规格	价格	数量
5 mg	￥ 490.00
10 mg	￥ 665.00
100 mg	￥ 3,430.00

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生物活性

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。

靶点信息

ROCK2	ROCK2
41 nM(Ki)	60 nM

溶解度 *

In vitro (25°C)	DMSO	84 mg/mL (185.63 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+35% PEG 300+2%Tween 80+ddH2O	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.1 mL	110.49 mL	220.99 mL
0.5 mM	4.42 mL	22.1 mL	44.2 mL
1 mM	2.21 mL	11.05 mL	22.1 mL
5 mM	0.44 mL	2.21 mL	4.42 mL

*The above data is based on the productmolecular weight 452.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15239
作用机制	Inhibitor (抑制剂)
M. Wt	452.51
Formula	C26H24N6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	911417-87-3
Synonyms	SLx 2119, SLx2119, ROCK inhibitor, KD-025
SMILES	CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5