SGLT

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Dapagliflozin (BMS512148)

Catalog No. A10285
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SGLT2 抑制剂

Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白（SGLT2）的亚型2，后者负责肾脏中至少90％的葡萄糖重吸收。了解更多

Product Citations (5)

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- David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
- Neil Tanday, .et al. Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta- to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance, Biochem Pharmacol, 2020, Jul;177:114009 PMID: 32360307
- Subramaniam M, .et al. Comparison of Intestinal Glucose Flux and Electrogenic Current Demonstrates Two Absorptive Pathways in Pig and One in Nile Tilapia and Rainbow Trout, Am J Physiol Regul Integr Comp Physiol, 2019, Nov 20 PMID: 31746628
- Marina Subramaniam, .et al. Sigmoidal kinetics define porcine intestinal segregation of electrogenic monosaccharide transport systems as having multiple transporter population involvement, Physiol Rep, 2019, May; 7(9): e14090 PMID: 31062524
- Angelopoulou A, .et al. Magnetic Nanoparticles for the Delivery of Dapagliflozin to Hypoxic Tumors: Physicochemical Characterization and Cell Studies, AAPS PharmSciTech, 2018, Feb;19(2):621-633 PMID: 8924948
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Canagliflozin

Catalog No. A11100
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SGLT2 抑制剂

canagliflozin是2型亚钠葡萄糖转运蛋白（SGLT2）的抑制剂,作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。了解更多

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- David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
- Angelopoulou A, .et al. Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy, Nanomedicine, 2018, Oct;13(19):2435-2454 PMID: 30311542
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EGT1442

Catalog No. A10155
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SGLT2 抑制剂

EGT1442是有效的选择性SGLT2抑制剂。了解更多

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Empagliflozin

Catalog No. A12440
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Empagliflozin是一种有效的选择性葡萄糖钠共转运蛋白-2抑制剂，目前正在开发中，用于治疗2型糖尿病。了解更多

Product Citations (3)

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- Yu-Jung Heo, .et al. Empagliflozin Reduces the Progression of Hepatic Fibrosis in a Mouse Model and Inhibits the Activation of Hepatic Stellate Cells via the Hippo Signalling Pathway, Biomedicines, 2022, Apr 29;10(5):1032 PMID: 35625768
- Nami Lee, .et al. Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF- κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways, J Immunol Res, 2021, Jun 2;2021:9944880 PMID: 34124273
- CN Koyani, .et al. Empagliflozin Protects Heart From Inflammation and Energy Depletion via AMPK Activation, Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052
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LX-4211

Catalog No. A12680
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SGLT 抑制剂?

LX4211是双重SGLT1/SGLT2抑制剂。了解更多

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Tofogliflozin

Catalog No. A12690
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SGLT2 抑制剂

Tofogliflozin是亚型2钠葡萄糖转运蛋白（SGLT2）的抑制剂，可引起肾脏中至少90％的葡萄糖重吸收。了解更多

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Remogliflozin

Catalog No. A13971
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SGLT2 抑制剂

Remogliflozin抑制钠葡萄糖转运蛋白（SGLT2），后者负责肾脏中的葡萄糖重吸收。了解更多

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Ipragliflozin

Catalog No. A13556
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SGLT2 抑制剂

Ipragliflozin是一种高效的选择性SGLT2抑制剂，IC50为2.8 nM。SGLT1/3/4/5/6的效力很小且没有效力。了解更多

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Luseogliflozin

Catalog No. A13476
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SGLT2 抑制剂

Luseogliflozin是由Taisho Pharmaceutical开发的一种口服活性第二代钠葡萄糖共转运蛋白2（SGLT2）抑制剂，用于治疗2型糖尿病（T2DM）患者。了解更多

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T-1095

Catalog No. A15463
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Na+-glucose transporter 抑制剂

T-1095是Na+-葡萄糖共转运蛋白（SGLTs）的有效和选择性抑制剂。了解更多

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Canagliflozin hemihydrate

Catalog No. A16817
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SGLT2 抑制剂

Canagliflozin hemihydrate是半水形式的卡格列嗪，是一种SGLT2抑制剂，在无细胞检测中hSGLT2的IC50为2.2 nM，其选择性比hSGLT1高413倍。了解更多

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Ertugliflozin L-pyroglutamic acid

Catalog No. A18054
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SGLT inhibitor

Ertugliflozin pidolate belongs to the class of potent and selective inhibitors of the sodium-dependent glucose cotransporters (SGLT), more specifically the type 2 which is responsible for about 90% of the glucose reabsorption from glomerulus. 了解更多

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SGL5213

Catalog No. A18723
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SGLT1 抑制剂

SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. 了解更多

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Dapagliflozin impurity

Catalog No. A19103
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SGLT2 抑制剂

Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor. 了解更多

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Licogliflozin

Catalog No. A12828
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SGLT1/SGLT2 抑制剂

Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor. 了解更多

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