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BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase 抑制剂BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。 了解更多 -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase 抑制剂DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
LY2811376
Catalog No. A11776 -
BMS 433796
Catalog No. A11337 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
LY3039478
Catalog No. A13544 -
JLK 6
Catalog No. A15301 -
PF-03084014
Catalog No. A11259 -
Flurbiprofen Axetil
Catalog No. A13662 -
L-685458
Catalog No. A15899 -
Begacestat (GSI-953)
Catalog No. A11258 -
Z-Ile-Leu-aldehyde
Catalog No. A16215 -
IMR-1A
Catalog No. A16223 -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多 -
Compound E
Catalog No. A21292 -
Verteporfin
Catalog No. A12658 YAP 抑制剂Verteporfin是抑制TEAD-YAP缔合和YAP诱导的肝过度生长的小分子。它也是一种有效的第二代光敏剂，衍生自卟啉。 了解更多 -
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最新产品
BIO
Catalog No. A17129 -
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VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多 -
CHIR-99021 monohydrochloride
Catalog No. A21430 GSK-3α/β inhibitorCHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. 了解更多 -
CHIR-99021 trihydrochloride
Catalog No. A21436 GSK-3α/β inhibitorCHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. 了解更多 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多 -
GSK-3 inhibitor 1
Catalog No. A21803 -
CHIR-98014
Catalog No. A11085 -
TWS119
Catalog No. A11223 -
Tideglusib
Catalog No. A11592 GSK-3 抑制剂Tideglusib是一种不可逆的，非ATP竞争性的GSK-3β抑制剂，无细胞试验中IC50为60 nM。用于治疗阿尔茨海默氏病和进行性核上性麻痹。 了解更多 -
AZD2858
Catalog No. A13060 -
AR-A 014418
Catalog No. A13728 GSK-3 抑制剂AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5（IC50值> 100μM）以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。 了解更多 -
1-Azakenpaullone
Catalog No. A14303 GSK-3β 抑制剂1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。 了解更多 -
IM-12
Catalog No. A14196 -
Bikinin
Catalog No. A15526 -
BIO-acetoxime
Catalog No. A15555 GSK-3 抑制剂BIO-acetoxime是一种有效的双重GSK3α/β抑制剂，IC50为10 nM，选择性比CDK5/p25，CDK2/cyclin A和 CDK1/cyclin B高240倍以上。 了解更多
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- Hedgehog (10)
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- γ-Secretase (24)
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