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Tacrine hydrochloride hydrate是乙酰（AChE）和丁酰胆碱酯酶（BChE）的抑制剂，IC50分别为31 nM和25.6 nM。
| In vitro | DMSO | 43 mg/mL | |
| Water | 43 mg/mL | ||
| Ethanol | 43 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 39.57 mL | 197.83 mL | 395.66 mL |
| 0.5 mM | 7.91 mL | 39.57 mL | 79.13 mL |
| 1 mM | 3.96 mL | 19.78 mL | 39.57 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.91 mL |
*The above data is based on the productmolecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16970 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 252.74 |
| Formula | C13H17ClN2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 206658-92-6 |
| Synonyms | THA hydrochloride hydrate, Tetrahydroaminacrine hydrochloride hydrate |
| SMILES | NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl.O |
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