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使用 'Aβ40' 作为标签的产品

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BMS-708163 (Avagacestat)

Catalog No. A10157
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Gamma-secretase 抑制剂

BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。了解更多

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MK-0752

Catalog No. A11194
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Gamma-secretase 抑制剂

MK-0752抑制Notch信号通路，这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。了解更多

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RO4929097

Catalog No. A10802
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Gamma-secretase 抑制剂

RO4929097是一种γ secretase抑制剂，无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。了解更多

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- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
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Semagacestat (LY450139)

Catalog No. A10836
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Gamma-secretase 抑制剂

Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。了解更多

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- Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079

Adooq Bioscience

使用 'Aβ40' 作为标签的产品

BMS-708163 (Avagacestat)

MK-0752

RO4929097

Semagacestat (LY450139)

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