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A-769662

Catalog No. A11071
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AMPK 激活剂

A-769662是AMP激活的蛋白激酶（AMPK）的新激活剂。了解更多

Product Citations (4)

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- Daniel Missailidis, .et al. Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts, Int J Mol Sci., 2021, Feb; 22(4): 2046 PMID: 33669532
- Lieberthal W, .et al. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo, Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
- Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
- Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200
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Acadesine (Aicar,NSC 105823)

Catalog No. A10028
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AMPK 激活剂

Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。了解更多

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- R. Lim, .et al. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators., Placenta, 2015, Apr;36(4):454-62 PMID: 25659498
- Stella Liong, .et al. Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women., J Physiol Biochem, 2015, Dec;71(4):703-17 PMID: 26407807
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BML-275 (Dorsomorphin)

Catalog No. A11970
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AMPK 抑制剂

BML-275 (Dorsomorphin)是一种可渗透细胞的吡唑并嘧啶化合物，显示为AMP激活的蛋白激酶（AMPK）和脂肪酸合酶抑制剂。了解更多

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- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
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Dorsomorphin 2HCl

Catalog No. A13720
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BMP 抑制剂

Dorsomorphin 2HCl (BML-275)是BMP信号传导的选择性小分子抑制剂，可促进胚胎干细胞的心肌发生。Dorsomorphin通过抑制骨形态发生蛋白信号转导逆转乳腺癌起始细胞的间质表型。了解更多

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- Kameshima S, .et al. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts, Apoptosis, 2019, Feb 8 PMID: 30737648
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ETC-1002

Catalog No. A15815
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ACL 抑制剂 and AMPK 激活剂

ETC-1002是一种新颖的，一流的可以降低LDL-C的小分子；肝AMP激活的蛋白激酶（AMPK）的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性（IC50 = 29 uM）。了解更多

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GSK621

Catalog No. A15896
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AMPK 激活剂

GSK621是有效的选择性AMPK激动剂。了解更多

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- Harvey W. Smith, .et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis, Nat Commun, 2019, 10, 2901(2019) PMID: 31263101
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Metformin HCl

Catalog No. A10573
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Metformin HCl降低肝细胞中高血糖症，主要通过抑制肝糖原的产生（肝脏糖异生作用)发挥作用。了解更多

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- Matthew A Schaller, .et al. Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses, JCI Insight, 2021, Sep 22;6(18):e148003 PMID: 34357881
- Matthew A. Schaller, .et al. In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response, bioRxiv, 2021, January 21
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Phenformin hydrochloride

Catalog No. A10717
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Phenformin hydrochloride是双胍类药物中苯乙双胍的盐酸盐，具有抗糖尿病活性。了解更多

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Adooq Bioscience

使用 'AMPK' 作为标签的产品

A-769662

Acadesine (Aicar,NSC 105823)

BML-275 (Dorsomorphin)

Dorsomorphin 2HCl

ETC-1002

GSK621

Metformin HCl

Phenformin hydrochloride

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