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使用 'ATM' 作为标签的产品

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CGK 733

Catalog No. A13191
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ATM/ATR 抑制剂

CGK733是ATR和ATM激酶的选择性抑制剂。在过早衰老的乳腺癌细胞中诱导细胞死亡。了解更多

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CP-466722

Catalog No. A11086
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ATM 抑制剂

CP-466722是一种特殊的ATM抑制剂，可抑制细胞依赖ATM的磷酸化事件，并且ATM功能的破坏会导致特征性的细胞周期检查点缺陷。了解更多

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ETP-46464

Catalog No. A13328
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ATR 抑制剂

ETP-46464是一种有效的选择性ATR抑制剂，IC50为25 nM。了解更多

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- Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
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KU-60019

Catalog No. A10507
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ATM 抑制剂

KU-60019是一种强效特异性ATM抑制剂，IC50为6.3 nM。了解更多

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- Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
- Hegedus C, .et al. PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis, Cancers (Basel), 2019, Dec 18;12(1) PMID: 31861350
- Masaya Igase, .et al. Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma, Mol Ther Oncolytics, 2019, vol 15 PMID: 31650025
- CHENGHUA LOU, .et al. Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells, Oncol Lett, 2016, Jul; 12(1): 295-300 PMID: 27347141
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NU-7441 (KU-57788)

Catalog No. A11098
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DNA-PK 抑制剂

NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。了解更多

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- Shahar Biechonski, .et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation, Sci Rep, 2018, Apr 17 PMID: 29666389
- Ihara M, .et al. Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines, J Radiat Res, 2018, Nov 23 PMID: 30476230
- Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201
- Masaaki Yanai, .et al. DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair, Yonago Acta Med, 2017, Mar; 60(1): 9-15 PMID: 28331416
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NU7026

Catalog No. A12752
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DNA-PK 抑制剂

NU7026是一种新型的在无细胞试验中IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。了解更多

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- Velichko AK, .et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription, Nucleic Acids Res, 2019, May 22. pii: gkz436 PMID: 31114877
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Torin 2

Catalog No. A11586
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mTOR 抑制剂

Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。了解更多

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- Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
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VE-822

Catalog No. A13289
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ATR 抑制剂

VE-822是有效的ATR抑制剂。了解更多

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Wortmannin

Catalog No. A11161
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PI3K 抑制剂

Wortmannin是一种有效的，选择性的，可透过细胞的且不可逆的磷脂酰肌醇3-激酶（PI 3-激酶）（IC50 = 2-4 nM）抑制剂，它也有效抑制polo-like激酶1（PLK1）（IC50 = 5.8 nM）。了解更多

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- Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.

Adooq Bioscience

使用 'ATM' 作为标签的产品

CGK 733

CP-466722

ETP-46464

KU-60019

NU-7441 (KU-57788)

NU7026

Torin 2

VE-822

Wortmannin

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