订阅到源订阅

使用 'c-Met' 作为标签的产品

Quick View
PF-2341066 (Crizotinib)

Catalog No. A10712
Quick View

添加到收藏
ALK/ c-Met 抑制剂

PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖（IC50 = 30 nM）。了解更多

Product Citations (6)

Bulk Inquiry Free Sample
- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Yu B, .et al. Pharmacokinetics and metabolism of ulixertinib in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry, J Sep Sci, 2020, Jan 22 PMID: 31970927
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
- Saki Omote, .et al. Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1, Sci Rep, 2018, 8: 9237 PMID: 29915248
- Arakawa H, .et al. Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2, J Pharm Sci, 2017, Sep;106(9):2899-2903 PMID: 28336299
Quick View
PF-04217903

Catalog No. A10711
Quick View

添加到收藏
c-Met 抑制剂

PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，在A549细胞中IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。了解更多

Bulk Inquiry Free Sample
Quick View
INCB28060

Catalog No. A11132
Quick View

添加到收藏
c-MET 抑制剂

INCB28060 (Capmatinib )是一种新型的，ATP竞争性c-MET抑制剂，无细胞试验中IC50为0.13 nM，对RONβ，EGFR和HER-3无活性。了解更多

Product Citations (1)

Bulk Inquiry
- Wei Deying,etc. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Biosci Rep. 2017 Apr 30; 37(2): BSR20160470.
Quick View
E-7050 (Golvatinib)

Catalog No. A11396
Quick View

添加到收藏
E-7050 (Golvatinib)是具有潜在抗肿瘤活性的c-Met(肝细胞生长因子受体)和VEGFR-2(血管内皮生长因子受体-2)酪氨酸激酶的口服生物可利用双重激酶抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
AMG 208

Catalog No. A10063
Quick View

添加到收藏
c-Met 抑制剂

AMG 208是一种新型c-Met抑制剂，可抑制c-Met的配体依赖性和配体依赖性活化，从而抑制其酪氨酸激酶活性。了解更多

Bulk Inquiry

Adooq Bioscience

使用 'c-Met' 作为标签的产品

PF-2341066 (Crizotinib)

PF-04217903

INCB28060

E-7050 (Golvatinib)

AMG 208

JOIN OUR REWARDS PROGRAM TODAY AND START EARNING POINTS RIGHT AWAY !

Total item