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使用 'Chk2' 作为标签的产品

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SCH 900776 (MK-8776)

Catalog No. A11167
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Chk1 抑制剂

SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1（Chk1）的药物，无细胞试验中IC50为3 nM，比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。了解更多

Product Citations (5)

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- Hong Yang, .et al. APOBEC3B Improves Response to PD-1 Blockade Through DSBs-ATR-CHK1 Pathway, Research Square, 2022, May 9th
- Motofumi Suzuki, .et al. Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer, Int J Radiat Oncol Biol Phys, 2021, May 25;S0360-3016(21)00361-8 PMID: 34112559
- Min Wu, .et al. FLT3/ITD Cooperates With Rac1 To Modulate The Sensitivity Of Leukemic Cells To Chemotherapeutic Agents Via Regulation Of DNA Repair Pathways, Haematologica, 2019, 104 PMID: 30975911
- Permata TBM, .et al. Base excision repair regulates PD-L1 expression in cancer cells, Oncogene, 2019, Feb 12 PMID: 30755733
- Hiro Sato, .et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells, Nat Commun, 2017, 8: 1751 PMID: 29170499
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PF 477736

Catalog No. A11520
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Chk 抑制剂

PF 477736是选择性检查点激酶1 (Chk1)抑制剂(Chk1和Chk2的ki值分别为0.49和47 nM)。了解更多

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AZD7762

Catalog No. A10113
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Chk1 & Chk2 抑制剂

AZD7762是一种有效的ATP竞争性检查点激酶抑制剂，可促进检查点废止并增强DNA靶向疗法。了解更多

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Adooq Bioscience

使用 'Chk2' 作为标签的产品

SCH 900776 (MK-8776)

PF 477736

AZD7762

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