使用 'class I PI3K isoforms' 作为标签的产品
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PI3K/mTOR Dual 抑制剂
LY3023414是从专利WO/2012097039A1(化合物实施例1)中提取的I类PI3K同种型,mTOR和DNA-PK的口服ATP竞争性抑制剂,对Akt1(pT308)的IC50为64.9 nM,42.1 nM,10.6 nM和19.1 nM。),Akt1(pS473),P70S6(pT389),S6RP(pS240/242)。
了解更多
- Zou Y, .et al. Targeting PI3K-AKT-mTOR by LY3023414 inhibits human skin squamous cell carcinoma cell growth in vitro and in vivo, Biochem Biophys Res Commun, 2017, Aug 19;490(2):385-392 PMID: 28623128