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XL-888

Catalog No. A11251
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HSP90 抑制剂

XL888是口服可生物利用的，具有ATP竞争性的小分子热休克蛋白90（Hsp90）抑制剂，IC50为24 nM。具有潜在的抗肿瘤活性。了解更多

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PU-H71

Catalog No. A11130
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Hsp90 抑制剂

PU-H71是有效的Hsp90抑制剂（IC50 = 50 nM）。了解更多

Product Citations (3)

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
- Kale S, .et al. HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators, Naunyn Schmiedebergs Arch Pharmacol, 2019, Sep 14 PMID: 31522240
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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PF-04929113 (SNX-5422)

Catalog No. A11074
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Hsp90 抑制剂

PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。了解更多

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- Henry Aceros, .et al. Celastrol-type HSP90 modulators allow for potent cardioprotective effects, Life Sci, 2019, 2019
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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Onalespib (AT13387)

Catalog No. A11062
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HSP90 抑制剂

Onalespib (AT13387)是Hsp90的靶向抑制剂，可抑制其伴侣功能并促进涉及肿瘤细胞增殖和存活的致癌信号蛋白的降解。了解更多

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- Boucherat O, .et al. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, 2018, Jul 1;198(1):90-103 PMID: 29394093
- Olivier Boucherat, .et al. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension, Sci Rep, 2017, 7: 4546 PMID: 28674407
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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NMS-E973

Catalog No. A14292
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HSP90 抑制剂

NMS-E973是一种有效的选择性Hsp90抑制剂。了解更多

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KW-2478

Catalog No. A11195
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HSP90 抑制剂

KW-2478是一种靶向人热休克蛋白90（Hsp90）的药物，具有潜在的抗肿瘤活性。了解更多

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- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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Geldanamycin

Catalog No. A11025
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Hsp90 抑制剂

Geldanamycin与Hsp90的ATP位点（Kd = 1.2μM）结合并抑制其分子伴侣活性。了解更多

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
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Ganetespib (STA-9090)

Catalog No. A11402
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Hsp90 抑制剂

Ganetespib (STA-9090)是Hsp90的有效合成小分子抑制剂，Hsp90是一种伴侣蛋白，对于某些其他蛋白的功能至关重要，这些蛋白可驱动许多不同类型的癌症的生长，增殖和存活。了解更多

Product Citations (6)

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- Tung-Yun Wu, .et al. Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment, J Adv Res, 2022, Jun 22;S2090-1232(22)00148-5 PMID: 35752438
- Aykut Ozgur, .et al. Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells, J Chemother, 2021, Apr 2;1-10 PMID: 33794753
- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
- Kosinsky RL, .et al. USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer, Cell Death Dis, 2019, Dec 4;10(12):911 PMID: 31801945
- Yamada-Kanazawa S, .et al. Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway, Br J Dermatol, 2017, Aug;177(2):456-469 PMID: 28078663
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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BIIB021

Catalog No. A10143
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HSP90 抑制剂

BIIB021是一种口服全合成Hsp90抑制剂，可选择性和有效地抑制分子伴侣Hsp90。了解更多

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- Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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17-DMAG HCl (Alvespimycin)

Catalog No. A10011
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Hsp90 抑制剂

17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。了解更多

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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
- Naoki Shiraishi, .et al. Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17?DMAG and ganetespib on tumor cells, Oncol Rep, 2020, 448-458 PMID: 33416122
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17-AAG (KOS953)

Catalog No. A10010
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HSP90 抑制剂

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。了解更多

Product Citations (1)

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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7

Adooq Bioscience

使用 'HSP90' 作为标签的产品

XL-888

PU-H71

PF-04929113 (SNX-5422)

Onalespib (AT13387)

NMS-E973

KW-2478

Geldanamycin

Ganetespib (STA-9090)

BIIB021

17-DMAG HCl (Alvespimycin)

17-AAG (KOS953)

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