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使用 'HSP90α' 作为标签的产品

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AUY922 (Luminespib, NVP-AUY922)

Catalog No. A10659
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HSP90 抑制剂

AUY922 (Luminespib,NVP-AUY922)是一种高效的HSP90抑制剂，在Hsp90 FP结合测定中的IC50 = 21 nM，并在体外抑制多种人类癌细胞系的增殖，GI50平均为9 nM。Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，无细胞试验中作用于HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何小分子HSP90配体均可紧密结合。了解更多

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- Haruka Wakasa, .et al. Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro, J Mammary Gland Biol Neoplasia, 2022, Jun;27(2):155-170 PMID: 35581442
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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CH5138303

Catalog No. A14282
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HSP90 抑制剂

CH5138303是Hsp90抑制剂，Kd为0.48 nM。了解更多

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HSP-990

Catalog No. A12850
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HSP90 抑制剂

HSP990是人热休克蛋白90（Hsp90）的口服生物利用抑制剂，对HSP90α/β的IC50分别为0.6 nM和0.8 nM。具有潜在的抗肿瘤活性。了解更多

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
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SNX-2112

Catalog No. A11189
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Hsp90 抑制剂

SNX-2112是目前在临床试验中具有抗癌特性的热激蛋白90（Hsp90）抑制剂。SNX-2112通过Akt/mTOR/p70S6K抑制以时间和剂量依赖的方式诱导自噬。SNX-2112在人黑素瘤A-375细胞中诱导明显的凋亡和自噬，可能是有效的靶向治疗剂。了解更多

Product Citations (2)

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Adooq Bioscience

使用 'HSP90α' 作为标签的产品

AUY922 (Luminespib, NVP-AUY922)

CH5138303

HSP-990

SNX-2112

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