使用 'IKCa1 (KCa3.1)' 作为标签的产品
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Potassium Channel Blocker
TRAM-34是中等电导Ca2+激活的K+通道(KCa3.1)(Kd = 20 nM)的高度选择性阻滞剂。在KV,BKCa,KCa2,Na+,CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。
了解更多
- Samuel Drinkall, .et al. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation, Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
- Cheong Hoon Seo, .et al. Altered K Ca 3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation, Transl Res, 2021, Apr 24 PMID: 33905948