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使用 'Mdm2' 作为标签的产品

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AMG232

Catalog No. A14394
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MDM2 抑制剂

AMG 232是MDM2-p53相互作用的高效，选择性生物利用的哌啶酮抑制剂（SPR KD = 0.045 nM，SJSA-1 EdU IC50 = 9.1 nM）。了解更多

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Idasanutlin (RG7388)

Catalog No. A14211
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MDM2/p53 抑制剂

Idasanutlin (RG7388)是一种有效的选择性p53-MDM2抑制剂。了解更多

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MDM2 Inhibitor

Catalog No. A13582
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MDM2 抑制剂

MDM2 Inhibitor是一种细胞可渗透的硼烷基查尔酮，表现出与MDM2的强结合，并不可逆地破坏MDM2/p53蛋白复合物。了解更多

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MI-773

Catalog No. A15440
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MDM2 抑制剂

MI-773是可用的MDM2拮抗剂，Ki为0.88 nM。了解更多

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Nutlin 3a

Catalog No. A11501
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MDM2 抑制剂

Nutlin 3a是与p53结合的MDM2(小鼠双分钟2)有效抑制剂，可诱导p53调控基因的表达，并在表达功能性p53的细胞中表现出有效的抗增殖活性。了解更多

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- Sho Watanabe, .et al. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis, J Crohns Colitis, 2021, Feb 17 PMID: 33596306
- Shun Zhang, .et al. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation, BPB Reports, 2019, 2, 130-133
- Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325
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Nutlin 3b

Catalog No. A11502
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MDM2 抑制剂

Nutlin 3b是p53/MDM2拮抗剂或抑制剂，IC50值为13.6 uM，与相反的（-）-对映体Nutlin-3a相比，Nutlin-3的有效（+）-对映体少150倍。了解更多

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Nutlin-3

Catalog No. A10657
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Mdm2 拮抗剂

Nutlin-3是一种有效的，选择性Mdm2(它自身和p53的环指依赖性泛素蛋白连接酶)拮抗剂，是有效的凋亡诱导剂。了解更多

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- Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749-1763 PMID: 29743291
- Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
- Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
- A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376
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p53 and MDM2 proteins-interaction-inhibitor chiral

Catalog No. A15201
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p53-MDM2 interaction 抑制剂

p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。了解更多

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p53 and MDM2 proteins-interaction-inhibitor racemic

Catalog No. A15202
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p53-MDM2 interaction 抑制剂

p53和MDM2蛋白相互作用抑制剂消旋体是p53和MDM2蛋白之间相互作用的抑制剂。了解更多

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RITA (NSC 652287)

Catalog No. A11931
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p53 activator

RITA，也称为NSC 652287，是一种三环噻吩衍生物，与MDM2结合，破坏MDM2-p53复合物，随后激活p53，并诱导凋亡。了解更多

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- M Kobayashi, .et al. Nutlin-3a Suppresses Poly (ADP-ribose) Polymerase 1 by Mechanisms Different From Conventional PARP1 Suppressors in a Human Breast Cancer Cell Line, Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340
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Tenovin-1

Catalog No. A11943
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p53 activator

Tenovin-1是p53转录活性的小分子激活剂，可防止MDM2介导的p53降解。了解更多

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WR 1065

Catalog No. A15353
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P53/p21waf-1/MDM2 activator

WR 1065是一种氨磷汀（Ethyol）的去磷酸化代谢产物，可防止受到辐射的直接和延迟影响。了解更多

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YH239-EE

Catalog No. A14118
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Mdm2 抑制剂

YH239-EE是有效的p53-MDM2拮抗剂和凋亡诱导剂。了解更多

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Adooq Bioscience

使用 'Mdm2' 作为标签的产品

AMG232

Idasanutlin (RG7388)

MDM2 Inhibitor

MI-773

Nutlin 3a

Nutlin 3b

Nutlin-3

p53 and MDM2 proteins-interaction-inhibitor chiral

p53 and MDM2 proteins-interaction-inhibitor racemic

RITA (NSC 652287)

Tenovin-1

WR 1065

YH239-EE

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