使用 'Notch S3 cleavage' 作为标签的产品
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Gamma secretase 抑制剂
LY-411575是一种选择性的,细胞可渗透的小分子γ-secretase抑制剂。在表达APP或NΔE的HEK293细胞中IC50为0.078 nM/0.082 nM(基于膜/细胞),也抑制Notch分裂,IC50为0.39 nM。
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- Wojciech J Szlachcic, .et al. SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis, iScience, 2022, Jul 15;25(7) PMID: 35756892
- Zhang ZH, .et al. Notch signaling suppresses CD14+ monocytes cells activity in patients with chronic hepatitis C, APMIS, 2019, Jul 5 PMID: 31274210
- Bo Pang, .et al. Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma, Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
- Shuo Li, .et al. Notch signaling pathway suppresses CD8+ T cells activity in patients with lung adenocarcinoma, Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
- Jiang BC, .et al. Notch Signaling Regulates Circulating T Helper 22 Cells in Patients with Chronic Hepatitis C, Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452