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使用 'p110α' 作为标签的产品

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GDC-0980 (Apitolisib, RG7422)

Catalog No. A11023
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mTOR/PI3K 抑制剂

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。了解更多

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- Kasun Wanigasooriya, .et al. Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer, Front Oncol, 2022, Jul 4;12:920444 PMID: 35860583
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LY294002

Catalog No. A10547
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PI3K 抑制剂

LY294002是PI3k抑制剂（IC50约为10μM）和酪蛋白激酶II抑制剂。了解更多

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- Ming-Chun Hung, .et al. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer, Cell Biosci, 2022, 12: 122 PMID: 35918763
- Chien-Feng Li, .et al. EMP2 induces cytostasis and apoptosis via the TGF β/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma, Cell Oncol (Dordr), 2021, Aug 2 PMID: 34339014
- Hiroharu Sakai, .et al. BRAP2 inhibits the Ras/Raf/MEK and PI3K/Akt pathways in leukemia cells, thereby inducing apoptosis and inhibiting cell growth, Exp Ther Med, 2021, March 5 PMID: 33747195
- Cheng Zhou, .et al. GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia, Cell Death Dis, 2021, Mar 3;12(3):231 PMID: 33658491
- Daniel Limonta, .et al. Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain, J Infect Dis, 2019, 2019 PMID: 30799482
- Lv H, .et al. CXCL8 gene silencing promotes neuroglial cells activation while inhibiting neuroinflammation through the PI3K/Akt/NF-κB-signaling pathway in mice with ischemic stroke, J Cell Physiol, 2018, Oct 26 PMID: 30362547
- Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170
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PF-4989216

Catalog No. A12889
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PI3K 抑制剂

PF-4989216是一种有效的选择性PI3K抑制剂，对p110α，p110β，p110γ，p110δ和VPS34的IC50分别为2 nM，142 nM，65 nM，1 nM和110 nM。了解更多

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PIK-293

Catalog No. A10727
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PI3K 抑制剂

PIK-293是PI3-K抑制剂。PIK-293抑制p110α，p110β，p110δ。PIK-293是PIK-294的母体化合物。了解更多

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PIK-75 hydrochloride

Catalog No. A10729
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PI3K 抑制剂

PIK-75是一种p110α抑制剂，IC50值为5.8nM。在p110γ和p110β的效果较差，IC50值为0.076 ?M和1.3 ?M。了解更多

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- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
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YM201636

Catalog No. A11064
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PI3K 抑制剂

YM201636是PIKfyve的细胞渗透性和选择性抑制剂（IC50 = 33 nM）。了解更多

Product Citations (2)

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- Krishna Chintaluri, .et al. The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells, PLoS One, 2018, 13(6): e0198454 PMID: 29870544
- Dayam RM, .et al. The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase, J Immunol, 2017, Sep 15;199(6):2096-2105 PMID: 28779020

Adooq Bioscience

使用 'p110α' 作为标签的产品

GDC-0980 (Apitolisib, RG7422)

LY294002

PF-4989216

PIK-293

PIK-75 hydrochloride

YM201636

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