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使用 'p38α MAPK' 作为标签的产品

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VX-745

Catalog No. A10983
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p38 MAPK 抑制剂

VX-745是一种有效的，选择性p38α抑制剂，IC50为10 nM，比作用于p38β选择性高22倍，对p38γ没有抑制作用。了解更多

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Skepinone-L

Catalog No. A11321
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p38 MAPK 抑制剂

Skepinone-L是选择性p38丝裂原活化蛋白激酶抑制剂。了解更多

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- Ramona Rudalska, etc. In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nat Med. 2014 Oct; 20(10): 1138–1146.
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SB 239063

Catalog No. A11562
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p38 MAPK 抑制剂

SB 239063是一种强效选择性p38 MAPKα/β抑制剂(p38α的IC50=44 nM)。SB 239063对ERK, JNK1和其他激酶的选择性超过220倍；比SB 203580的选择性高约3倍。SB 239063减少炎症细胞因子的产生，并在体内口服后具有神经保护作用。了解更多

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SB 202190

Catalog No. A10823
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p38 MAPK 抑制剂

SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。了解更多

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- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
- Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215
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PH-797804

Catalog No. A11078
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p38 MAPK 抑制剂

PH-797804是p38丝裂原活化蛋白（MAP）激酶的二芳基吡啶酮抑制剂。了解更多

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- Yuho Ito, .et al. MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway, Biosci Biotechnol Biochem, 2015, 79(11):1794-801 PMID: 26057585
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Pamapimod (R-1503)

Catalog No. A13551
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p38 MAPK 抑制剂

Pamapimod (R-1503)是一种新型p38丝裂原活化蛋白激酶抑制剂。了解更多

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LY2228820 (Ralimetinib)

Catalog No. A10545
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p38 MAPK 抑制剂

LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。了解更多

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Losmapimod (GW856553X)

Catalog No. A12526
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p38 MAPK 抑制剂

Losmapimod，也称为GW856553或GW856553X，是葛兰素史克（GlaxoSmithKline）开发的药物，可作为酶家族的选择性抑制剂，称为p38促分裂原活化蛋白激酶，其作用于p38α和p38β的pKi分别为8.1和7.6 。了解更多

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Doramapimod (BIRB-796)

Catalog No. A10148
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p38 MAPK 抑制剂

Doramapimod（BIRB 796）是p38 MAPK的小分子抑制剂，在调节促炎细胞因子的产生中起关键作用。了解更多

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- Ken Kobayashi, .et al. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation, Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
- Junsuke Uwada, .et al. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK, Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
- Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019

Adooq Bioscience

使用 'p38α MAPK' 作为标签的产品

VX-745

Skepinone-L

SB 239063

SB 202190

PH-797804

Pamapimod (R-1503)

LY2228820 (Ralimetinib)

Losmapimod (GW856553X)

Doramapimod (BIRB-796)

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