订阅到源订阅

使用 'PDGFR' 作为标签的产品

Quick View
Tyrphostin AG 879

Catalog No. A10053
Quick View

添加到收藏
HER2 抑制剂

Tyrphostin AG 879是神经生长因子（NGF）TrkA酪氨酸激酶活性的抑制剂。了解更多

Bulk Inquiry
Quick View
PD168393

Catalog No. A12725
Quick View

添加到收藏
EGFR 抑制剂

PD168393是一种有效的，细胞可渗透的，不可逆的EGFR抑制剂，IC50值为700 pM。了解更多

Bulk Inquiry
Quick View
Imatinib Mesylate

Catalog No. A10468
Quick View

添加到收藏
Bcr-Abl 抑制剂

Imatinib mesylate是一种选择性酪氨酸激酶抑制剂，通过抑制KIT信号转导途径，在治疗胃肠间质瘤中诱导了持续的客观反应。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Inge Govaerts, .et al. PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia, J Hematol Oncol, 2021, 14: 97 PMID: 34167562
- Genevra Kuziel, .et al. Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells, Cancers (Basel), 2020, Jul 28;12(8):E2083 PMID: 32731354
Quick View
Imatinib (Gleevec)

Catalog No. A10259
Quick View

添加到收藏
PDGFR 抑制剂

Imatinib (Gleevec)是一种多靶点酪氨酸激酶抑制剂，抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6，0.1和0.1 μM。了解更多

Product Citations (6)

Bulk Inquiry Free Sample
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Takafumi Shima, .et al. Glucose transporter-1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells, Oncol Rep, 2022, 47: 7 PMID: 34738628
- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- BM Duggan, .et al. RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice, Endocrinology, 2020, May 30;bqaa086 PMID: 32473019
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
Quick View
AG-17

Catalog No. A11949
Quick View

添加到收藏
EGFR 抑制剂

AG-17是人表皮样癌细胞系A431中EGFR激酶的抑制剂，IC50值为460 μM，作用于PDGFR更有效，IC50值为0.5μM。了解更多

Bulk Inquiry
Quick View
AG-1478 (Tyrphostin AG-1478)

Catalog No. A11022
Quick View

添加到收藏
EGFR 抑制剂

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
- Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733

Adooq Bioscience

使用 'PDGFR' 作为标签的产品

Tyrphostin AG 879

PD168393

Imatinib Mesylate

Imatinib (Gleevec)

AG-17

AG-1478 (Tyrphostin AG-1478)

JOIN OUR REWARDS PROGRAM TODAY AND START EARNING POINTS RIGHT AWAY !

Total item