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使用 'PERK' 作为标签的产品

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GSK2656157

Catalog No. A13577
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PERK 抑制剂

GSK2656157是PERK酶活性的ATP竞争性抑制剂，IC50为0.9 nmol/L。对于PER（K）IC50值> 100 nmol/L，对300种激酶组合具有高度选择性。了解更多

Product Citations (2)

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- Cao W, .et al. Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue, J Cell Mol Med, 2019, Aug 23 PMID: 31441588
- Kosuke Ishikawa, .et al. A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes, Biology Methods and Protocols, 2018, 1–10
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ISRIB

Catalog No. A14302
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PERK 抑制剂

ISRIB是一种有效的选择性PERK抑制剂，IC50为5 nM。了解更多

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- Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis, Proc Natl Acad Sci U S A, 2021, May 18;118(20) PMID: 33972447
- Satoshi Watanabe, .et al. Resetting proteostasis with ISRIB prevents pulmonary fibrosis, bioRxiv, 2020, February 27
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ISRIB (trans-isomer)

Catalog No. A13816
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PERK 抑制剂

ISRIB (trans-isomer)是一种有效的选择性小分子PERK信号抑制剂（IC50?5 nM），可以有效逆转eIF2α磷酸化的作用。了解更多

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