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使用 'PI3K' 作为标签的产品

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Deguelin

Catalog No. A13460
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Deguelin是一种天然产物，具有很强的抗增殖活性。了解更多

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GNE-317

Catalog No. A13992
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PI3K 抑制剂

GNE-317是一种有效的PI3K抑制剂，可以穿过血液的脑屏障。显示了完整BBB小鼠大脑中PI3K途径的有效抑制。了解更多

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Miltefosine

Catalog No. A14138
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PI3K/Akt 抑制剂

Miltefosine在癌细胞系A431和HeLa中抑制PI3K/Akt活性，ED50为17.2μM和8.1μM。了解更多

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NU-7441 (KU-57788)

Catalog No. A11098
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DNA-PK 抑制剂

NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。了解更多

Product Citations (4)

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- Shahar Biechonski, .et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation, Sci Rep, 2018, Apr 17 PMID: 29666389
- Ihara M, .et al. Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines, J Radiat Res, 2018, Nov 23 PMID: 30476230
- Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201
- Masaaki Yanai, .et al. DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair, Yonago Acta Med, 2017, Mar; 60(1): 9-15 PMID: 28331416
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NU7026

Catalog No. A12752
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DNA-PK 抑制剂

NU7026是一种新型的在无细胞试验中IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。了解更多

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- Velichko AK, .et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription, Nucleic Acids Res, 2019, May 22. pii: gkz436 PMID: 31114877
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Wortmannin

Catalog No. A11161
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PI3K 抑制剂

Wortmannin是一种有效的，选择性的，可透过细胞的且不可逆的磷脂酰肌醇3-激酶（PI 3-激酶）（IC50 = 2-4 nM）抑制剂，它也有效抑制polo-like激酶1（PLK1）（IC50 = 5.8 nM）。了解更多

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- Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.
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ZSTK474

Catalog No. A11014
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PI3K 抑制剂

ZSTK474是I类磷脂酰肌醇3激酶同工型的ATP竞争性抑制剂。了解更多

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- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Adooq Bioscience

使用 'PI3K' 作为标签的产品

Deguelin

GNE-317

Miltefosine

NU-7441 (KU-57788)

NU7026

Wortmannin

ZSTK474

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