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使用 'PI3Kα' 作为标签的产品

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AMG319

Catalog No. A15901
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PI3Kδ 抑制剂

AMG319是一种有效的选择性PI3Kδ抑制剂，IC50为18 nM，选择性是其他PI3K的47倍以上。了解更多

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AS-252424

Catalog No. A11099
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PI3K 抑制剂

AS-252424是有效的PI3K抑制剂，对γ亚型具有选择性。它抑制人重组PI3Kγ，α，β和δ，IC50值分别为30、940、20,000和20,000 nM。了解更多

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AS-605240

Catalog No. A10088
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PI3K 抑制剂

AS-605240是PI3激酶γ抑制剂，以ATP竞争的方式抑制人重组PI3Kγ，α，β和δ，IC50值为8、60、270和300 nM。了解更多

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AZD6482

Catalog No. A10112
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PI3K 抑制剂

AZD6482是一种PI3Kβ抑制剂，(IC50 = 0.021M)。了解更多

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BAY 80-6946 (Copanlisib)

Catalog No. A11766
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PI3K 抑制剂

BAY 80-6946 (Copanlisib)是具有潜在抗肿瘤活性的磷酸肌醇3激酶（PI3K）抑制剂。了解更多

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- Shin SM, .et al. Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth, Sci Adv, 2020, Jan 15;6(3):eaay2174 PMID: 31998840
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BYL719 (Alpelisib)

Catalog No. A11328
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PI3K 抑制剂

BYL719 (Alpelisib)是一种口服生物可利用的磷脂酰肌醇3-激酶(PI3K)抑制剂，抑制 p110α/p110γ/p110δ/p110β 的 IC50 分别为 5 nM，250 nM，290 nM，1200 nM 。具有潜在的抗肿瘤活性。了解更多

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- Lisann Pelzl, .et al. Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent, J Thromb Haemost, 2022, Feb;20(2):387-398 PMID: 34752677
- J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
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CC-223

Catalog No. A13078
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mTOR 抑制剂

CC-223是一种有效的mTOR激酶抑制剂（IC50 = 16 nM），其敏感性是相关脂质激酶PI3K-alpha（IC50 = 4 uM）的> 150倍。了解更多

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ETP-46464

Catalog No. A13328
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ATR 抑制剂

ETP-46464是一种有效的选择性ATR抑制剂，IC50为25 nM。了解更多

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- Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
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GDC-0349

Catalog No. A11443
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mTOR 抑制剂

GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。了解更多

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GSK1059615

Catalog No. A10438
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mTOR/PI3K 抑制剂

GSK1059615是PI3Kα (IC50 = 2 nM)的强效、可逆、ATP竞争性噻唑烷二酮抑制剂。了解更多

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- Jing Xie, .et al. GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway, Oncotarget, 2017, Aug 1; 8(31): 50814-50823 PMID: 28881606
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HS-173

Catalog No. A13021
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PI3K 抑制剂

HS-173是一种新型磷脂酰肌醇3激酶（PI3K）抑制剂，通过促进细胞凋亡和抑制血管生成而具有抗肿瘤活性。了解更多

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- Mostafa Khater, .et al. Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK, J Biol Chem, 2021, Jan-Jun, 296:100805 PMID: 34022220
- Mostafa Khater, .et al. G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers, J Biol Chem, 2021, Jan 22;296:100325 PMID: 33493514
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KU 0060648

Catalog No. A13224
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DNA-PK 抑制剂

KU0060648是一种有效且选择性的DNA依赖性蛋白激酶（DNA-PK）抑制剂（IC50 = 8.6 nM）；对DNA-PK的选择性是其他PIKK的20-1000倍，并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。了解更多

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NVP-BGT226

Catalog No. A11162
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PI3K 抑制剂

NVP-BGT226，新型磷酸肌醇3-激酶/mTOR双重抑制剂，作用于PI3Kα/β/γ，IC50为4 nM/63 nM/38 nM，在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。了解更多

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PIK-90

Catalog No. A10730
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PI3K 抑制剂

PIK-90是一种合成的磷酸肌醇3激酶（PI3K）抑制剂，对于p110α，β，γ和δ亚型的IC50值（nM）为11、350、18和58，mTOR活性低。了解更多

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PKI-402

Catalog No. A11089
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PI3K 抑制剂

PKI-402是一种有效的，pan-PI3K/mTOR双重抑制剂，靶向作用于PI3Kα/β/γ/δ和mTOR，IC50分别为2 nM/7 nM/16 nM/14 nM和3 nM，也有效作用于PI3Kα突变型E545K和H1047R。了解更多

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PKI-587 ( Gedatolisib )

Catalog No. A11079
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PI3K/mTOR 抑制剂

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。了解更多

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TG 100713

Catalog No. A11956
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PI3K 抑制剂

TG 100713是PI3K的抑制剂，可抑制内皮细胞的增殖。了解更多

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TG100-115

Catalog No. A10922
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PI3K 抑制剂

TG100-115是一种PI3Kγ/δ抑制剂（IC50值分别为83和235 nM）。了解更多

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VS-5584

Catalog No. A12480
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PI3K/mTOR 抑制剂

VS-5584是一种新型且高度选择性的PI3K/mTOR激酶抑制剂，可用于治疗癌症。了解更多

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XL-147 (Pilaralisib)

Catalog No. A15283
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PI3K 抑制剂

XL-147 (Pilaralisib)是I类PI3K脂质激酶家族有效的生物利用抑制剂。了解更多

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ZSTK474

Catalog No. A11014
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PI3K 抑制剂

ZSTK474是I类磷脂酰肌醇3激酶同工型的ATP竞争性抑制剂。了解更多

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- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Adooq Bioscience

使用 'PI3Kα' 作为标签的产品

AMG319

AS-252424

AS-605240

AZD6482

BAY 80-6946 (Copanlisib)

BYL719 (Alpelisib)

CC-223

ETP-46464

GDC-0349

GSK1059615

HS-173

KU 0060648

NVP-BGT226

PIK-90

PKI-402

PKI-587 ( Gedatolisib )

TG 100713

TG100-115

VS-5584

XL-147 (Pilaralisib)

ZSTK474

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